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KMID : 0380220070400060979
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Journal of Biochemistry and Molecular Biology
2007 Volume.40 No. 6 p.979 ~ p.985
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Induction of Growth Hormone Release by Glycyrrhizae Radix on Rat
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Lee Ho-Young
Jung Dae-Young
Ha Hye-Kyung
Kang Sam-Sik
Kim Ju-Sun
Kim Chung-Sook
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Abstract
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Induction of growth hormone (GH) by Glycyrrhizae Radix (GR), one of the most popular herbal medicine, and its major ingredients were studied in rat pituitary cells in vitro and in vivo assay. The MeOH extract and the n-hexane (HX) fraction of GR induced rat GH (rGH) release up to 1.89 times (0.34 ± 0.04 nM) and 4.59 times (0.83 ± 0.03 nM), compared to the basal level (p < 0.05). Among many ingredients isolated and purified from GR both glycyrrhetinic acid and glycyrrhizin induced significantly rGH release compared to the control (p < 0.05). After an intravenous injection of rat growth hormone releasing hormone (rGHRH) (10 μg/kg) as positive control, in SD rats, Tmax of plasma rGH level was 10 min, Cmax was 3.84 ± 0.01 nM (n = 3), and enhanced plasma rGH level returned to the baseline in 90 min. Both AUC0-90 (area under the curve) of plasma rGH level after HX fraction and that after rGHRH administration were increased significantly from the basal level, respectively (p < 0.01). In conclusions, HX fraction is the most active fraction of MeOH extract of GR in rGH induction.
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KEYWORD
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Glycyrrhizin, Glycyrrhizae Radix, Growth hormone (GH), Growth hormone releasing hormone (GHRH), Growth hormone secretagogue (GHS), Pituitary cells
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